Researchers: Rosa Artells and Ricard Pruna
Introduction: In recent years, studies have begun to be published, showing the importance of the genetic component in the pathogenesis of soft tissue noncontact injuries.
Objetives: To analyze the relationship between genetic polymorphisms (SNPs) in the genes involved in tissue repair and regeneration and the possible relationship with the repair, tissue regeneration, injury incidence, plus time of recovery of the tissue non-contact injuries.
Material y Methods: We analyzed the blood of 73 professional football players and record the soft tissue noncontact injuries (type, grade and recovery time) of them. The SNPs analyzed were: Elastin (ELN); Titin (TTN), SRY-related HMG-box (SOX15), Insulin-like growth factor 2 (IGF2) Chemokine, CC motif, ligand 2 (CCL2), Collagen type I alpha1 (COL1A1), type 5 Collagen alpha 1 (COL5A1) and Tenascin C (TNC). The analysis of the SNP was performed by allelic discrimination technique.
Results: There were 242 injuries. 203 were muscle, correlating with the degree of injury IGF2 (p = 0.032). We observed a trend between the degree of damaged muscle and CCL2 (p = 0.013) and COL5A1 (p = 0.07). 24 patients were joint elastin interacting with the degree of injury (p = 0.009) and recovery time (p = 0.027). There was no relationship between the SNPs studied and grade or recovery time of 15 tendon injuries.
Conclusions: SNPs in IGF2, CCL2, COL5A1 and ELN can relate to the degree of the injury and the recovery time of non-contact soft tissue injuries.
Utility: Knowing this information and determine the genetic profile of professional athletes can be useful, as the perpetrators of this study showed, in the way to plan training to try to minimize the risk of injury in those genetically predisposed players and to anticipate the recovery time when they occurred.
Figure1: Relationship IGF2, CCL2 and COL5A1 with the degree of muscle injury. A) Individuals heterozygous GC IGF2 submits minor injuries. B) The presence of the C allele in a genotype conferred protective CCL2 regarding the severity of the injury. C) Tendency to show that the presence of the T allele could lead to more serious injuries individual.
Figure 2: Relationship of the ELN to the degree of injury and the recovery time ligamentous injuries. A) The absence of allele G imply that the individual suffer more serious injuries. B) The presence of the G allele determines that individuals submit faster recovery times.
Table: Genotype frequencies related to the severity